In 1828 Scotland, Edinburgh surgeon Dr. Knox does medical research on cadavers he buys from murderers Burke and Hare, without questioning the unethical procurement methods.
When Dakota tries to break off her toxic relationship with Axel, it starts transforming him into a monstrous creature. He gradually succumbs to the poison of the decaying relationship, becoming a creature with increased aggression, a touch that melts skin and worst of all, he's contagious.