While hunting in the jungle, one day, Vijay save the life of a young man from the sudden attack of a wild hawk. There and then Vijay realizes that he have just save the life of a miraculous snake who have the powers to take the form of a human and who have been dating his beloved; also a miraculous female snake. Vijay browse this news to his five friends who immediately shoot the male snake to death. Enraged at the brutal killing of her beloved; the female snake begins to take revenge on the six friends, killing them one by one by taking the form of humans. Now the only one who can save the six friends is a sage but it certainly looks like the miraculous snake might as well do away with all her enemies before the sage lay hands on her.
故事紧接着上一集发展,小狗贝多芬和露西终于走到了一起,过上了幸福的生活,露西还为贝多芬生下了四只可爱的小狗,一家人其乐融融。然而,这四只小狗崽却让孩子们陷入了烦恼之中,如果让爸爸知道家里一下子多了这四个小家伙,那还不非得翻了天不可。 虽然挨了老爸一顿臭骂,但善良的布鲁诺先生(凯文·杜恩 Kevin Dunn 饰)还是收留了贝多芬和露西的孩子们,一家人前往宁静的小村开始了悠闲的度假。然而他们并不知道的是,布鲁诺的前妻瑞吉娜(黛比·玛扎 Debi Mazar 饰)早已经盯上了小狗崽们,她想将它们偷到手,卖掉大赚一笔。得知此事的贝多芬率先行动,带领妻儿躲到了山中,瑞吉娜紧随其后。