It's a love story about a husband and wife, played by Jake Johnson and Rosemarie DeWitt. It's about the pleasures and pains of building a family with someone, and maintaining the excitement of a relationship over a long period of time.
Clay is a young man in a small town who witnesses his friend kill himself because of the on-going affair that Clay was having with the man's wife. Feeling guilty, Clay now resists the widow when she presses him to continue with their sexual affairs. Clay befriends a troubling serial killer.
Old Nat Moyer is a talker, a philosopher, and a troublemaker with a fanciful imagination. His companion is Midge Carter, who is half-blind, but still the super of an apartment house. When he is threatened with retirement, Nat battles on his behalf. Nat also takes on his daughter, a drug dealer, and a mugger in this appealing version of a really 'odd couple'